Preimplantion genetic screening PGS

PGS is an effective tool of embryo selection. The objective of PGS is to improve pregnancy results by selecting only chromosomally normal embryos for transfer. The method is particularly beneficial for women over 35 years as well as for patients with recurrent miscarriage or several failed fertility treatments. Generally, the treatment results are improved irrespective of the woman´s age if only chromosomally normal embryos are transferred.

From forty to fifty percent of morphologically normal appearing embryos of a young woman may be chromosomally abnormal , i.e. aneuploid. Women over 40 years may have up to 75-90% of aneuploid embryos. The majority of chromosomal abnormalities lead to total arrest of embryonic development or early miscarriage.

Source: US CDC/SART (left), Harton et al. (2013) Fertility and Sterility 106:1695-703 (right)

In PGS treatments samples of 4-8 cells are taken from five to six day old embryos and the embryos are cryopreserved by vitrification. The embryos that were diagnosed as chromosomally normal can be transferred into the uterus. With the aid of PGS, ineffective embryo transfers are avoided and a pregnancy rates even exceeding 70% may be achieved.

In PGS treatments the embryos are cultured in a time-lapse incubator (EmbryoScope®) which furher improves embryo selection. Ask more information about Ovumia Fertinovas PGS embryo selection process!

Ask more about PGD/PGS:

Peter Bredbacka

 

Peter Bredbacka
PGD/PGS specialist
peter.bredbacka@ovumia.fi