Preimplantation genetic diagnosis PGD

Recent developments in embryo cultures, freezing technologies and DNA analyses have considerably improved and extended the uses of embryo diagnostics. Ovumia Fertinova has invested significantly in the introduction of modern DNA diagnostics and the developement of Reproductive biology methods over the last three years. Embryo diagnoses are utilised to examine individual genetic disorders and changes in chromosome count.

Pre-implantation genetic diagnosis, or PGD, helps couples who are at risk of having a child with a serious hereditary disorder.

In PGD, embryos fertilised through in vitro fertilisation are cultured for 5 days, after which a biopsy of 3-5 cells is taken from the embryos that have reached the blastocyst stage. Biopsied embryos are frozen using the vitrification method, which is more reliable than the traditional freezing process, because it improves the embryos’ post-thaw survival rate and consequently the chances of pregnancy. Based on the results of the analysis, the chosen embryos can later be transferred to the womb.

In principle, any known genetic disorder can be examined using pre-implantation genetic diagnosis. Embryos can also be screened for hereditary abnormalities in their chromosome structure, such as translocations (chromosome PGD).

Ask more about PGD/PGS:

Peter Bredbacka

 

Peter Bredbacka
PGD/PGS specialist
peter.bredbacka@ovumia.fi